Moving toward offering the very first therapy for treating epidermolysis bullosa (EB), InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) recently announced it has signed an agreement with Pharmaseed Ltd. (http://nnw.fm/4lZzC) to develop a final formulation for INM-750, InMed’s lead compound, which is being developed as a therapy for EB and for other potential dermatological and wound-healing applications.
EB is a group of inherited connective tissue diseases sharing a common manifestation of very fragile skin that is prone to easily blistering or tearing. An orphan disease that currently has no approved treatments and has significant unmet medical need, EB results from a defect in anchoring between the dermis and the epidermis and is most commonly caused by the absence of specific keratins in the skin. In addition to its effects on the skin, EB can also affect bodily systems and internal organs.
InMed’s INM-750 is a proprietary topical product candidate that includes multiple cannabinoids as its active ingredients, which were chosen to modulate keratin levels in EB patients in anticipation of having a disease-modulating effect. A secondary reason for selecting these cannabinoids was to address EB symptoms, including inflammation, wound healing, skin regeneration, itching and pain. In development as a topical application, INM-750 is designed to optimize penetration of the cannabinoids to the skin’s epidermal/dermal junction.
Through the agreement with Pharmaseed, which is the largest GLP-certified preclinical contract research organization in Israel, InMed is taking another step toward moving INM-750 to its first clinical trial. Under the terms of the agreement, Pharmaseed will develop a final formulation for INM-750 for ongoing R&D, including IND-enabling pharmacology and toxicology studies and eventual clinical studies. The contract also includes the development of assay methods for manufacturing, stability, quality assurance and other methods of analysis.
A preclinical-stage biopharmaceutical company, InMed specializes in the research and development of cannabinoid-based prescription drug therapies that utilize novel drug delivery systems. For its product candidates, the company conducts research, discovery, preclinical, clinical, regulatory, manufacturing and commercial development activities. InMed’s primary value drivers are its proprietary bioinformatics database assessment tool, biosynthesis manufacturing process and drug development programs.
For more information, visit the company’s website at www.InMedPharma.com
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